Aricept

Aricept is a medication primarily used to treat symptoms of Alzheimer’s disease. The active ingredient in Aricept is donepezil. It enhances the function of nerve cells in the brain by inhibiting an enzyme that breaks down acetylcholine, a chemical important for memory. Aricept is also known by the generic name donepezil or as donepezil hydrochloride. This drug helps improve mental functions like memory and attention in individuals diagnosed with Alzheimer’s. Aricept is available in tablet form and is taken orally. It is prescribed by healthcare professionals after a thorough diagnosis and assessment.

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Aricept Price Details

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The Aricept price is approximately £0.6 – £0.99 per pills. Depending on the size of the pack and the number of tablets inside (30 or 360 mg).

Medication Classification

Aricept, known generically as donepezil, is classified as a cholinesterase inhibitor. It is primarily used in the treatment of cognitive symptoms related to Alzheimer’s disease. The medication works by increasing levels of acetylcholine in the brain, a neurotransmitter associated with memory and learning. By inhibiting the breakdown of acetylcholine, Aricept aims to enhance cognitive function and slow symptom progression in patients with dementia. It is important to understand that Aricept is not a cure for Alzheimer’s disease but is used to manage and alleviate symptoms associated with the condition.

Pharmaceutical Presentation

Aricept is presented in tablet forms that come in various dosages, specifically in strengths of 5 mg, 10 mg, and 23 mg. The tablets are film-coated, facilitating easier ingestion and potentially reducing gastrointestinal irritation. The 23 mg dose also comes in an extended-release format, allowing for once-daily dosing and maintaining even drug levels in the blood over a 24-hour period. These dosing forms offer flexibility in treatment regimens and enable titration to the most effective dose for each individual patient as directed by a healthcare professional.

Dosing Recommendations

Initial dosing of Aricept generally starts at 5 mg once daily, administered orally at bedtime. After 4 to 6 weeks, based on clinical response and tolerability, the dose may be increased to 10 mg once daily. The 23 mg dose is reserved for patients who have tolerated the 10 mg dose for at least 3 months and require additional therapeutic benefit. Health care providers should tailor dosing to individual needs while considering potential risks inherent in higher dosages.

Pharmacodynamics and Pharmacokinetics

Upon oral administration, Aricept displays a rapid absorption with peak plasma concentrations occurring approximately 3 to 4 hours post-dose. The presence of food does not significantly affect the overall bioavailability of the drug. The half-life of donepezil is approximately 70 hours, which supports once-daily dosing. Donepezil is metabolized predominantly by the cytochrome P450 system (specifically CYP 2D6 and CYP 3A4 isoenzymes) and partly through glucuronidation, with renal and fecal pathways involved in excretion.

Drug Interactions

Concomitant use of Aricept with certain medications can lead to significant interactions. Caution is necessary when using drugs that affect the CYP 2D6 or CYP 3A4 enzyme pathways, as these can influence donepezil’s plasma levels. Additionally, medications with anticholinergic effects may reduce the efficacy of Aricept. Combining with other cholinergic drugs or inhibitors like succinylcholine can exacerbate cholinergic side effects, requiring careful monitoring.

Cognitive Assessment Criteria

The effectiveness of Aricept is often evaluated through cognitive assessments conducted by healthcare professionals. Tools like the Mini-Mental State Examination (MMSE) or the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) are frequently employed to quantify changes in cognitive function over time. Baseline evaluations should be established before initiation, followed by regular assessments to determine therapeutic benefits and dose adjustments.

Storage and Handling Instructions

Aricept should be stored at room temperature, between 15°C and 30°C (59°F and 86°F), away from moisture and light. It is vital to keep the medication in its original container, tightly closed, to protect it from degradation and contamination. Patients should be instructed to keep the medication out of reach of children and pets. Discard any expired or unused medication according to local regulations to avoid environmental contamination or accidental ingestion. Proper handling ensures the medication maintains its effectiveness throughout the treatment duration.

Specific Population Considerations

While Aricept is widely prescribed for patients with Alzheimer’s, its use in certain populations requires caution. Elderly patients may demonstrate variable tolerability due to age-related pharmacokinetic changes. The prescriber should consider potential co-morbidities and existing medications in this demographic. Rigorous evaluations are necessary when contemplating use in pregnant or nursing women, as insufficient data exists on potential effects. Pediatric use is not indicated, aligning with regulatory guidelines. Each patient’s profile must be individually considered to ensure the safe administration of Aricept.

Dosage

10mg, 5mg

Active ingredient

Donepezil

Pack

120 pills, 180 pills, 270 pills, 30 pills, 360 pills, 60 pills, 90 pills

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Aricept
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