Diflucan

Diflucan is a medication used to treat fungal infections. Its active ingredient is fluconazole. Diflucan is sometimes known by other names, such as Trican or AFUNGIL. It works by stopping the growth of certain types of fungus, helping to clear up the infection.

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Diflucan Price Details

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The Diflucan price is approximately £0.57 – £4.62 per pills. It depends on the pack size and the amount of active ingredient (30 or 360 mg).

Medication Overview for Diflucan

Diflucan, known by its generic name, fluconazole, is an antifungal medication. It’s primarily used to treat a wide range of fungal infections, including yeast infections of various types. Its action mechanism involves inhibiting the growth of fungi, thereby eliminating the infection.

Mechanism of Action

Fluconazole works by inhibiting an enzyme needed by the fungi to produce ergosterol, an essential component of the fungal cell membrane. Without ergosterol, the cell membrane becomes compromised, leading to the death of the fungus. This mechanism is specific to the azole class of antifungal drugs, which includes Diflucan.

Available Dosage Forms

Diflucan is available in multiple dosage forms to suit different needs. These include oral tablets, oral suspension, and intravenous solution. The tablets come in several strengths, typically ranging from 50 mg to 200 mg. The oral suspension is offered in a powder form that is reconstituted with water before use. The intravenous form is typically used in hospital settings for severe infections.

Treatment Indications

Diflucan is indicated for the treatment of various fungal infections. It is commonly used to treat vaginal yeast infections, thrush, esophageal candidiasis, and systemic fungal infections. Additionally, Diflucan is sometimes prescribed for the prevention of fungal infections in immunocompromised patients, such as those undergoing chemotherapy or those with HIV/AIDS.

Pharmacokinetics and Metabolism

Fluconazole is well-absorbed orally, with bioavailability exceeding 90%. The drug reaches peak plasma concentrations within 1-2 hours of ingestion. It has a half-life of approximately 30 hours, allowing for once-daily dosing in most treatment regimens. Unlike many other antifungal agents, fluconazole penetrates well into all body fluids and tissues, including the cerebrospinal fluid, making it effective for treating central nervous system infections.

Standard Dosage Recommendations

The dosage of Diflucan varies depending on the type and severity of the infection. For vaginal yeast infections, a single 150 mg oral dose is often sufficient. For candidemia and other serious systemic infections, dosing may start at 400 mg on the first day, followed by 200 mg once daily. Duration of therapy also depends on the infection and response to treatment.

Potential Side Effects

Common side effects may include headache, nausea, abdominal pain, and diarrhea. Rare but serious side effects can involve liver toxicity and cardiac arrhythmias. Patients should contact their healthcare provider if they experience symptoms of severe side effects or allergic reactions.

Special Population Considerations

In pregnant women, Diflucan should generally be avoided, particularly high doses for prolonged durations, due to potential teratogenic effects. For nursing mothers, Diflucan is secreted in breast milk but is generally considered safe after a single low dose. In elderly patients and those with renal impairment, dose adjustments may be necessary due to changes in drug clearance.

Drug Interactions

Fluconazole has the potential to interact with several other medications. It is a moderate inhibitor of the cytochrome P450 system, particularly the CYP2C9 and CYP3A4 isoenzymes. As a result, it can increase the levels of drugs metabolized by these pathways, such as warfarin, leading to increased bleeding risk. Concomitant use with other medications that prolong the QT interval should be approached with caution.

Monitoring and Efficacy

Patients on Diflucan should undergo periodic monitoring of liver function tests, especially with long-term use or in those with pre-existing liver conditions. Clinical efficacy is generally assessed through the resolution of symptoms and, in some cases, laboratory tests to confirm the eradication of the fungal infection.

Storage and Stability

Diflucan tablets should be stored at room temperature, away from excess heat and moisture. The oral suspension should be discarded after 14 days if refrigerated. For the intravenous form, specific storage instructions are provided depending on the product used.

Resistance and Limitations

Fungal resistance to fluconazole can develop, particularly in immune-compromised patients or with prolonged use. Resistance is more commonly seen in non-albicans Candida species. Clinicians should consider susceptibility patterns when choosing antifungal therapy, especially in areas with known resistance issues.

Dosage

100mg, 150mg, 200mg, 400mg, 50mg

Active ingredient

Fluconazole

Pack

120 pills, 180 pills, 270 pills, 30 pills, 360 pills, 60 pills, 90 pills

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Diflucan
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