Flomax

Flomax is a medication with the active ingredient tamsulosin. It is also known by its generic name, tamsulosin hydrochloride, and the brand name, Tamsulosin. Flomax is primarily used to help improve urination in men with an enlarged prostate, a condition called benign prostatic hyperplasia (BPH). By relaxing the muscles in the prostate and bladder, it helps to relieve symptoms such as difficulty starting urination and needing to urinate frequently or urgently.

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Flomax Price Update

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The price scale for Flomax typically fluctuates between £0.59 and £1.03 per caps. Factors such as packaging dimensions and active ingredient ratio (30 or 360 mg) come into play.

Medication Overview

Flomax, generically known as Tamsulosin, is an alpha-1 adrenergic antagonist. It is primarily used to treat benign prostatic hyperplasia (BPH) in adult males. By selectively blocking receptors in the prostate and bladder neck, it facilitates easier urine flow, thereby alleviating urinary symptoms associated with BPH.

Chemical Composition and Formulation

Flomax contains the active ingredient Tamsulosin hydrochloride. It is usually presented in the form of a capsule for oral administration. The typical formulation includes excipients such as microcrystalline cellulose, methacrylic acid copolymer, triacetin, and talc, contributing to the drug’s controlled-release mechanism. Each capsule typically contains 0.4 mg of Tamsulosin.

Mechanism of Action

Tamsulosin works by acting as an antagonist to alpha-1 adrenergic receptors located in the smooth muscle of the prostate and bladder neck. This receptor blockade leads to muscle relaxation in these areas, reducing urinary symptoms like frequent urination, hesitancy, and incomplete bladder emptying. The high selectivity for alpha-1A receptors means Tamsulosin has a minimal effect on blood vessel constriction, making it less likely to cause orthostatic hypotension compared to non-selective alpha blockers.

Pharmacokinetics

After oral administration, Tamsulosin is absorbed in the gastrointestinal tract with peak plasma concentrations reaching within 4 to 7 hours under fasting conditions. Food can delay absorption, making it advisable to maintain consistency regarding meals when taking the medication. Tamsulosin is extensively metabolized in the liver and is primarily excreted in urine. Its half-life ranges between 9 to 13 hours, indicating a steady-state plasma concentration achievable after 5 days of consistent dosing.

Indications and Usage

Flomax is indicated exclusively for the treatment of benign prostatic hyperplasia in adult males. It aids in alleviating urinary symptoms associated with BPH, such as weak stream, incomplete evacuation, nocturia, and urgency. It is not suitable for use in treating hypertension or for use in women.

Dosage and Administration

The recommended dose for adults is 0.4 mg once daily, taken orally. Capsules should be swallowed whole, without crushing or chewing, as manipulating the capsule can affect the drug’s release mechanism. Dosing should be consistent with respect to meals, ideally taken after the same meal each day to optimize absorption and therapeutic effect. If there is no adequate response after two to four weeks, the dose may be increased to 0.8 mg daily based on a healthcare provider’s discretion. However, caution is advised when performing a dose escalation.

Potential Drug Interactions

Tamsulosin interactions are significant with strong CYP3A4 inhibitors like ketoconazole, which may increase Tamsulosin’s plasma concentration. Concurrent use with other alpha blockers or antihypertensive agents may cause additive hypotensive effects. Caution is advised when combined with phosphodiesterase inhibitors like sildenafil due to potential excessive blood pressure lowering. Careful review of a patient’s medication regimen is necessary to minimize interaction risks.

Side Effects and Adverse Reactions

Common side effects include dizziness, headache, runny or stuffy nose, or ejaculation disorders. These are generally mild to moderate. Rare but severe reactions include priapism, a prolonged and painful erection, which requires immediate medical attention. Intraoperative floppy iris syndrome has been associated with patients on or previously treated with Tamsulosin undergoing cataract surgery. Reporting adverse reactions to healthcare providers promptly can mitigate potential complications.

Population-Specific Considerations

Special populations, including those with renal or hepatic impairment, may require adjusted dosing or increased monitoring due to potentially altered pharmacokinetics. The drug’s safety and efficacy in pediatric populations remain unestablished, warranting restricted usage to adult males with BPH symptoms. For geriatric patients, cautious dosing and thorough monitoring are advisable due to potential sensitivity and comorbid conditions.

Storage and Handling

Flomax should be stored at room temperature, away from excessive heat and moisture. Keeping the medication in its original container with the lid tightly closed helps ensure its integrity. It should be kept out of reach of children and disposed of properly when expired or no longer needed. Patients are advised to adhere strictly to these guidelines for optimal safety and efficacy.

Dosage

0.2mg, 0.4mg

Active ingredient

Tamsulosin

Pack

120 caps, 180 caps, 270 caps, 30 caps, 360 caps, 60 caps, 90 caps

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Flomax
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