Orlistat

Orlistat is a medication that contains the active ingredient orlistat, which is also known by brand names like Alli and Xenical. It is used primarily to assist people in losing weight or preventing weight regain. Orlistat works by blocking some of the fat you eat from being absorbed in your intestines, helping to reduce overall calorie intake. This medication is typically recommended alongside a doctor-approved diet and exercise plan to maximize its effectiveness.

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Price of Orlistat

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The standard rate for Orlistat oscillates between £0.95 and £5.16 for each caps. It’s contingent on the package dimensions and ingredient intensity (10 or 360 mg).

Medication Overview: Orlistat

Orlistat is a pharmaceutical agent classified as a lipase inhibitor, used primarily for the management of obesity. Its primary mechanism of action involves inhibiting the absorption of dietary fats by blocking pancreatic and gastric lipases. This medication should be prescribed as part of a comprehensive weight management program, including a reduced-calorie diet and exercise.

Dosage and Administration Guidelines

The typical dosage of Orlistat is 120 mg, administered orally three times a day with each main meal containing fat. Patients should be advised to adhere strictly to this regimen to maximize efficacy. If a meal is missed or contains no fat, the dose of Orlistat may be omitted. Treatment should ideally commence under the supervision of a healthcare professional to ensure optimal results and monitoring of progress.

Pharmacological Mechanism

Orlistat functions by binding to the serine residues of gastric and pancreatic lipases, thereby preventing these enzymes from hydrolyzing dietary triglycerides into absorbable free fatty acids and monoglycerides. This action results in a reduction of fat absorption by approximately 30%, contributing to a caloric deficit and promoting weight loss. It exhibits minimal absorption in the gastrointestinal tract, and its systemic effects are negligible.

Therapeutic Indications

Orlistat is primarily indicated for obesity management, including weight loss and maintenance, in individuals with a body mass index (BMI) of 30 kg/m² or greater. It is also prescribed for overweight individuals with a BMI of 27 kg/m² or higher who present with associated risk factors such as hypertension, diabetes, and dyslipidemia. Incorporating Orlistat into a structured weight-loss program supports better health outcomes in such populations.

Effects on Nutrient Absorption

The use of Orlistat results in decreased fat absorption, which may impact the uptake of fat-soluble vitamins (A, D, E, and K) and other nutrients. To mitigate potential deficiencies, patients are advised to take a multivitamin supplement containing these vitamins at least two hours before or after administering Orlistat. Continuous monitoring of vitamin levels might be necessary for those on extended treatment durations.

Potential Drug Interactions

Orlistat may interfere with the absorption and effectiveness of certain medications, such as ciclosporin, levothyroxine, and amiodarone. Patients are encouraged to inform healthcare providers about all current medications to manage potential interactions effectively. Adjustments to dosing schedules or additional monitoring may be required to avoid therapeutic inconsistencies.

Common Adverse Reactions

Commonly reported side effects of Orlistat include gastrointestinal issues such as oily or fatty stools, urgent bowel movements, and frequent bowel movements. These effects typically occur due to the unabsorbed fat being excreted in the feces and may reduce over time as the body adjusts to the medication. Patients should be informed of these potential side effects to set proper expectations when starting therapy.

Contraindications and Precautions

Orlistat is contraindicated in individuals with chronic malabsorption syndrome and cholestasis. Caution is advised in patients with existing kidney problems, as they may be at increased risk for hyperoxaluria and oxalate nephropathy. Monitoring kidney function and counseling patients on appropriate dietary modifications can help manage these risks effectively.

Special Population Considerations

In geriatric patients, considerations should be made regarding the decline in hepatic and renal function that might affect the drug’s safety and efficacy profile. While no dosage adjustments are routinely required for elderly patients, careful monitoring of response and tolerance is advisable. Limited data exist on the use of Orlistat in pediatric populations, and its use is generally not recommended for children under 12 years of age.

Storage and Handling Instructions

Orlistat should be stored at room temperature, away from excessive heat, moisture, and direct light. Keeping the medication in its original packaging ensures protection against degradation. Ensure the medicine is kept out of reach of children to prevent accidental ingestion, and only dispense Orlistat with a proper prescription label as per applicable regulations.

Monitoring Treatment Progress

Regular follow-ups with healthcare providers are crucial for assessing the effectiveness of Orlistat as part of a weight management regimen. Clinical monitoring may include tracking weight changes, assessing dietary habits, and evaluating potential side effects. Adjustments in therapy could be warranted based on the patient’s progress and tolerance over time.

Dosage

120mg, 60mg

Active ingredient

orlistat

Pack

10 caps, 120 caps, 180 caps, 270 caps, 30 caps, 360 caps, 60 caps, 90 caps

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Orlistat
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